8D46

Cryo-electron microscopy structure of human kidney Aldehyde Dehydrogenase 1A1

PDB DOI: https://doi.org/10.2210/pdb8D46/pdb
EM Map EMD-27176: EMDB EMDataResource

Classification: HYDROLASE
Organism(s): Homo sapiens
Expression System: Homo sapiens
Mutation(s): No

Deposited: 2022-06-01 Released: 2022-11-16
Deposition Author(s): Lyu, M., Yu, E.W.
Funding Organization(s): National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)

Experimental Data Snapshot

Method: ELECTRON MICROSCOPY
Resolution: 2.84 Å
Aggregation State: PARTICLE
Reconstruction Method: SINGLE PARTICLE

wwPDB Validation 3D Report Full Report

This is version 1.1 of the entry. See complete history.

Literature

Cryo-electron microscopy structure of human kidney Aldehyde Dehydrogenase 1A1

Lyu, M., Yu, E.W.

To be published.

Macromolecule Content

Total Structure Weight: 219.7 kDa
Atom Count: 15,110
Modelled Residue Count: 1,956
Deposited Residue Count: 2,004
Unique protein chains: 1

Macromolecules

Find similar proteins by:

(by identity cutoff) | 3D Structure

Entity ID: 1
Molecule	Chains	Sequence Length	Organism	Details	Image
Retinal dehydrogenase 1	A, B [auth C], C [auth D], D [auth B]	501	Homo sapiens	Mutation(s): 0 Gene Names: ALDH1A1, ALDC, ALDH1, PUMB1 EC: 1.2.1 (PDB Primary Data), 1.2.1.36 (PDB Primary Data), 1.2.1.19 (UniProt), 1.2.1.28 (UniProt), 1.2.1.3 (UniProt)
UniProt & NIH Common Fund Data Resources
Find proteins for P00352 (Homo sapiens) Explore P00352 Go to UniProtKB: P00352
PHAROS: P00352 GTEx: ENSG00000165092
Entity Groups
Sequence Clusters	30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt Group	P00352
Sequence Annotations Expand
Reference Sequence

Experimental Data & Validation

Experimental Data

Method: ELECTRON MICROSCOPY
Resolution: 2.84 Å
Aggregation State: PARTICLE
Reconstruction Method: SINGLE PARTICLE

Structure Validation

View Full Validation Report

Entry History & Funding Information

Deposition Data

Released Date: 2022-11-16

Deposition Author(s):

Funding Organization	Location	Grant Number
National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)	United States	R01 AI145069

Revision History (Full details and data files)

Version 1.0: 2022-11-16
Type: Initial release
Version 1.1: 2024-06-12
Changes: Data collection

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.