Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
DSCOP2B SuperfamilyMHC antigen-recognition domain 8034484 3000521 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyImmunoglobulin (Ig) domain-like 8055664 3000071 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyMHC antigen-recognition domain 8034484 3000521 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyImmunoglobulin (Ig) domain-like 8054679 3000071 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyMHC antigen-recognition domain 8041502 3000521 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyImmunoglobulin (Ig) domain-like 8054679 3000071 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyMHC antigen-recognition domain 8041502 3000521 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyImmunoglobulin (Ig) domain-like 8054555 3000071 SCOP2B (2022-06-29)
HSCOP2B SuperfamilyImmunoglobulin (Ig) domain-like 8054555 3000071 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
DC1-set_2e4gg6D2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_2ECOD (1.6)
DMHC_II_betae4gg6D3 A: a+b two layersX: MHC antigen-recognition domain (From Topology)H: MHC antigen-recognition domain (From Topology)T: MHC antigen-recognition domainF: MHC_II_betaECOD (1.6)
BC1-set_2e4gg6B1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_2ECOD (1.6)
BMHC_II_betae4gg6B2 A: a+b two layersX: MHC antigen-recognition domain (From Topology)H: MHC antigen-recognition domain (From Topology)T: MHC antigen-recognition domainF: MHC_II_betaECOD (1.6)
GDUF1968e4gg6G6 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: DUF1968ECOD (1.6)
GV-set_3e4gg6G5 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_3ECOD (1.6)
EDUF1968e4gg6E2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: DUF1968ECOD (1.6)
EV-set_3e4gg6E1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_3ECOD (1.6)
CC1-set_2e4gg6C1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_2ECOD (1.6)
CMHC_II_alphae4gg6C2 A: a+b two layersX: MHC antigen-recognition domain (From Topology)H: MHC antigen-recognition domain (From Topology)T: MHC antigen-recognition domainF: MHC_II_alphaECOD (1.6)
AC1-set_2e4gg6A1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_2ECOD (1.6)
AMHC_II_alphae4gg6A2 A: a+b two layersX: MHC antigen-recognition domain (From Topology)H: MHC antigen-recognition domain (From Topology)T: MHC antigen-recognition domainF: MHC_II_alphaECOD (1.6)
FC1-sete4gg6F3 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-setECOD (1.6)
FV-set_3e4gg6F4 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_3ECOD (1.6)
HC1-sete4gg6H3 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-setECOD (1.6)
HV-set_3e4gg6H4 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_3ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

IMGT Antibody Annotation IMGT Database Homepage

ChainProtein NameDescriptionOrganism NameGene Allele Name(s)Domain Name(s)Receptor TypeReceptor DescriptionProvenance Source
B, D
MH2 HLA-DQA1*0301, peptide fused to N-terminus of PEPTIDE-II-BETA Homo sapiens (human) HLA-DQB1*0302 G-DOMAIN G-BETA, C-LIKE-DOMAIN C-LIKE MH MH2-ALPHA_PEPTIDE-BETA IMGT (202449-0)
E, G
G-BETA_HLA-DBQ1*0302 TR-ALPHA Homo sapiens (human) TRAV26-2*01, TRAJ45*01, TRAC*01 V-DOMAIN V-ALPHA, C-DOMAIN C-ALPHA TR TR-ALPHA_BETA-2 IMGT (202449-0)
A, C
MH2 HLA-DQA1*0301, peptide fused to N-terminus of II-ALPHA Homo sapiens (human) HLA-DQA1*0301 G-DOMAIN G-ALPHA, C-LIKE-DOMAIN C-LIKE MH MH2-ALPHA_PEPTIDE-BETA IMGT (202449-0)
F, H
G-BETA_HLA-DBQ1*0302 TR-BETA-2 Homo sapiens (human) TRBV9*01, TRBV9*03, TRBJ2-7*01, TRBC2*01, TRBC2*02 V-DOMAIN V-BETA, C-DOMAIN C-BETA-2 TR TR-ALPHA_BETA-2 IMGT (202449-0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
B, D
PF00969Class II histocompatibility antigen, beta domain (MHC_II_beta)Class II histocompatibility antigen, beta domain- Domain
B, D
PF07654Immunoglobulin C1-set domain (C1-set)Immunoglobulin C1-set domain- Domain
E, G
PF07686Immunoglobulin V-set domain (V-set)Immunoglobulin V-set domainThis domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.Domain
E, G
PF09291Domain of unknown function (DUF1968) (DUF1968)Domain of unknown function (DUF1968)Members of this family are found in mammalian T-cell antigen receptor, and adopt an immunoglobulin-like beta-sandwich fold, with seven strands in two beta-sheets in a Greek-key topology. Their exact function has not, as yet, been determined.Domain
A, C
PF07654Immunoglobulin C1-set domain (C1-set)Immunoglobulin C1-set domain- Domain
A, C
PF00993Class II histocompatibility antigen, alpha domain (MHC_II_alpha)Class II histocompatibility antigen, alpha domain- Domain
F, H
PF07654Immunoglobulin C1-set domain (C1-set)Immunoglobulin C1-set domain- Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
B, D
HLA class II histocompatibility antigen, DQ beta 1 chain
E, G
T-CELL RECEPTOR, SP3.4 ALPHA CHAIN- - -
A, C
HLA class II histocompatibility antigen, DQ alpha 1 chain
F, H
T-CELL RECEPTOR, SP3.4 BETA CHAIN-
I, J
Peptide from Alpha/beta-gliadin MM1 - -

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
B, D
IPR036179Immunoglobulin-like domain superfamilyHomologous Superfamily
B, D
IPR050160Major Histocompatibility Complex/ImmunoglobulinFamily
B, D
IPR003597Immunoglobulin C1-setDomain
B, D
IPR011162MHC classes I/II-like antigen recognition proteinHomologous Superfamily
B, D
IPR003006Immunoglobulin/major histocompatibility complex, conserved siteConserved Site
B, D
IPR000353MHC class II, beta chain, N-terminalDomain
B, D
IPR014745MHC class II, alpha/beta chain, N-terminalHomologous Superfamily
B, D
IPR013783Immunoglobulin-like foldHomologous Superfamily
B, D
IPR007110Immunoglobulin-like domainDomain
E, G
IPR052051T cell receptor complex componentFamily
E, G
IPR013783Immunoglobulin-like foldHomologous Superfamily
E, G
IPR036179Immunoglobulin-like domain superfamilyHomologous Superfamily
E, G
IPR013106Immunoglobulin V-set domainDomain
E, G
IPR003599Immunoglobulin domain subtypeDomain
E, G
IPR007110Immunoglobulin-like domainDomain
E, G
IPR015370T-cell receptor alpha chain, constant domainDomain
A, C
IPR036179Immunoglobulin-like domain superfamilyHomologous Superfamily
A, C
IPR050160Major Histocompatibility Complex/ImmunoglobulinFamily
A, C
IPR003597Immunoglobulin C1-setDomain
A, C
IPR011162MHC classes I/II-like antigen recognition proteinHomologous Superfamily
A, C
IPR003006Immunoglobulin/major histocompatibility complex, conserved siteConserved Site
A, C
IPR014745MHC class II, alpha/beta chain, N-terminalHomologous Superfamily
A, C
IPR013783Immunoglobulin-like foldHomologous Superfamily
A, C
IPR007110Immunoglobulin-like domainDomain
A, C
IPR001003MHC class II, alpha chain, N-terminalDomain
F, H
IPR003597Immunoglobulin C1-setDomain
F, H
IPR013783Immunoglobulin-like foldHomologous Superfamily
F, H
IPR036179Immunoglobulin-like domain superfamilyHomologous Superfamily
F, H
IPR007110Immunoglobulin-like domainDomain
F, H
IPR050380Immune Recognition and Response ModulatorsFamily
I, J
IPR001954Gliadin/LMW gluteninFamily
I, J
IPR036312Bifunctional inhibitor/plant lipid transfer protein/seed storage helical domain superfamilyHomologous Superfamily
I, J
IPR016140Bifunctional inhibitor/plant lipid transfer protein/seed storage helical domainDomain

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
B, D
PharosP01920
A, C
PharosP01909