4MID | pdb_00004mid

Crystal Structure of Activin A/BMP2 chimera

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4mida_	Small proteins	Cystine-knot cytokines	Cystine-knot cytokines	automated matches	automated matches	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	TGF_beta	e4midA1	A: few secondary structure elements	X: Cystine-knot cytokines (From Topology)	H: Cystine-knot cytokines (From Topology)	T: Cystine-knot cytokines	F: TGF_beta	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.10.90.10	Mainly Beta	Ribbon	Cystine Knot Cytokines, subunit B	Cystine-knot cytokines	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00019	Transforming growth factor beta like domain (TGF_beta)	Transforming growth factor beta like domain		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	AB204 Activin A/BMP2 chimera	protein binding binding molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity growth factor activity receptor ligand activity signaling receptor activator activity protein-containing complex binding amide binding peptide hormone binding hormone binding identical protein binding protein binding binding molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity growth factor activity receptor ligand activity signaling receptor activator activity protein-containing complex binding amide binding peptide hormone binding hormone binding identical protein binding cytokine activity hormone activity activin receptor binding receptor serine/threonine kinase binding type II activin receptor binding transmembrane receptor protein serine/threonine kinase binding enzyme regulator activity enzyme activator activity phosphatase activator activity phosphatase regulator activity protein serine/threonine kinase activator activity kinase activator activity protein kinase activator activity protein kinase regulator activity kinase regulator activity BMP receptor binding co-receptor binding	developmental process multicellular organismal process gonad development reproductive system development reproductive process sex differentiation animal organ development developmental process involved in reproduction male gonad development male sex differentiation multicellular organism development development of primary male sexual characteristics development of primary sexual characteristics anatomical structure development reproductive structure development developmental process multicellular organismal process gonad development reproductive system development reproductive process sex differentiation animal organ development developmental process involved in reproduction male gonad development male sex differentiation multicellular organism development development of primary male sexual characteristics development of primary sexual characteristics anatomical structure development reproductive structure development system development cellular response to stimulus positive regulation of cell communication cell surface receptor protein serine/threonine kinase signaling pathway regulation of cellular process positive regulation of signal transduction response to stimulus signaling regulation of transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette signal transduction enzyme-linked receptor protein signaling pathway positive regulation of cellular process regulation of biological process regulation of signaling cell surface receptor signaling pathway biological regulation positive regulation of intracellular signal transduction positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway SMAD protein signal transduction regulation of response to stimulus regulation of cell communication cellular process regulation of SMAD protein signal transduction positive regulation of SMAD protein signal transduction positive regulation of signaling response to sterol response to lipid response to alcohol response to oxygen-containing compound response to cholesterol cellular response to oxygen-containing compound cellular response to chemical stimulus cellular response to alcohol response to chemical cellular response to lipid cellular response to sterol cellular response to cholesterol response to cytokine cytokine-mediated signaling pathway response to peptide cellular response to cytokine stimulus olefinic compound biosynthetic process small molecule biosynthetic process ketone metabolic process steroid metabolic process lipid biosynthetic process primary metabolic process testosterone biosynthetic process biosynthetic process olefinic compound metabolic process metabolic process small molecule metabolic process steroid biosynthetic process ketone biosynthetic process lipid metabolic process regulation of hormone levels androgen metabolic process regulation of biological quality hormone metabolic process signal transduction in absence of ligand regulation of programmed cell death positive regulation of extrinsic apoptotic signaling pathway in absence of ligand extrinsic apoptotic signaling pathway positive regulation of apoptotic signaling pathway extrinsic apoptotic signaling pathway in absence of ligand positive regulation of programmed cell death regulation of apoptotic process positive regulation of extrinsic apoptotic signaling pathway cell death positive regulation of apoptotic process regulation of extrinsic apoptotic signaling pathway apoptotic signaling pathway regulation of extrinsic apoptotic signaling pathway in absence of ligand apoptotic process programmed cell death regulation of apoptotic signaling pathway regulation of biosynthetic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process positive regulation of macromolecule biosynthetic process regulation of gene expression positive regulation of metabolic process positive regulation of gene expression positive regulation of biosynthetic process regulation of macromolecule biosynthetic process positive regulation of macromolecule metabolic process macromolecule metabolic process regulation of metabolic process response to decreased oxygen levels cellular response to oxygen levels cellular response to hypoxia cellular response to decreased oxygen levels cellular response to stress response to hypoxia response to stress response to oxygen levels response to abiotic stimulus catabolic process autophagy process utilizing autophagic mechanism regulation of leukocyte differentiation myeloid leukocyte differentiation cellular developmental process regulation of developmental process negative regulation of biological process cell development regulation of cell differentiation mononuclear cell differentiation regulation of cell development cell differentiation negative regulation of cellular process regulation of immune system process regulation of multicellular organismal process negative regulation of cell differentiation negative regulation of macrophage differentiation regulation of macrophage differentiation negative regulation of hemopoiesis regulation of multicellular organismal development negative regulation of leukocyte differentiation hemopoiesis regulation of myeloid cell differentiation negative regulation of developmental process macrophage differentiation regulation of myeloid leukocyte differentiation negative regulation of myeloid cell differentiation negative regulation of myeloid leukocyte differentiation negative regulation of cell development myeloid cell differentiation negative regulation of immune system process immune system process regulation of hemopoiesis negative regulation of multicellular organismal process leukocyte differentiation androst-4-ene-3,17-dione biosynthetic process cell-cell signaling regulation of growth regulation of cellular component organization growth negative regulation of cell growth regulation of cell growth cell growth cellular component organization negative regulation of growth cellular component organization or biogenesis defense response female gonad development female sex differentiation development of primary female sexual characteristics ovarian follicle development homeostatic process positive regulation of developmental process positive regulation of cell differentiation myeloid cell homeostasis erythrocyte homeostasis erythrocyte differentiation regulation of erythrocyte differentiation positive regulation of erythrocyte differentiation multicellular organismal-level homeostasis positive regulation of myeloid cell differentiation homeostasis of number of cells nervous system development anatomical structure morphogenesis odontogenesis animal organ morphogenesis cellular response to gonadotropin stimulus response to endogenous stimulus response to gonadotropin cellular response to endogenous stimulus response to hormone cellular response to follicle-stimulating hormone stimulus response to follicle-stimulating hormone cellular response to hormone stimulus regulation of localization system process regulation of system process negative regulation of transport negative regulation of follicle-stimulating hormone secretion localization negative regulation of secretion negative regulation of hormone secretion negative regulation of secretion by cell follicle-stimulating hormone secretion establishment of localization regulation of secretion endocrine hormone secretion negative regulation of gonadotropin secretion regulation of endocrine process regulation of hormone secretion gonadotropin secretion transport negative regulation of signaling hormone secretion negative regulation of cell communication secretion by cell regulation of secretion by cell signal release regulation of follicle-stimulating hormone secretion secretion regulation of transport regulation of gonadotropin secretion export from cell endocrine process hormone transport regulation of type II interferon production type II interferon production cytokine production regulation of cytokine production negative regulation of type II interferon production negative regulation of macromolecule metabolic process negative regulation of metabolic process negative regulation of cytokine production negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process response to aldosterone response to ketone response to mineralocorticoid response to corticosteroid response to steroid hormone collagen biosynthetic process regulation of collagen biosynthetic process regulation of collagen metabolic process positive regulation of collagen metabolic process positive regulation of collagen biosynthetic process collagen metabolic process positive regulation of DNA-templated transcription RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of DNA-templated transcription generation of neurons neurogenesis neuron differentiation GABAergic neuron differentiation forebrain development central nervous system neuron differentiation striatum development subpallium development striatal medium spiny neuron differentiation head development forebrain generation of neurons brain development central nervous system development telencephalon development forebrain neuron differentiation epithelial cell differentiation Sertoli cell differentiation epithelium development tissue development positive regulation of protein metabolic process regulation of protein metabolic process protein metabolic process positive regulation of ERK1 and ERK2 cascade positive regulation of MAPK cascade regulation of MAPK cascade MAPK cascade ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade formation of primary germ layer embryonic morphogenesis embryo development gastrulation endoderm development anatomical structure formation involved in morphogenesis endoderm formation endodermal cell differentiation epidermis development molting cycle process hair cycle skin development skin epidermis development hair follicle development molting cycle hair cycle process activin receptor signaling pathway transforming growth factor beta receptor superfamily signaling pathway regulation of leukocyte activation regulation of cell activation lymphocyte differentiation negative regulation of lymphocyte differentiation negative regulation of leukocyte activation lymphocyte activation negative regulation of lymphocyte activation leukocyte activation regulation of B cell differentiation B cell differentiation regulation of B cell activation negative regulation of B cell activation negative regulation of B cell differentiation regulation of lymphocyte differentiation B cell activation cell activation negative regulation of cell activation regulation of lymphocyte activation phosphorylation negative regulation of phosphate metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of phosphorus metabolic process regulation of phosphorus metabolic process regulation of phosphorylation negative regulation of phosphorylation phosphorus metabolic process positive regulation of multicellular organismal process positive regulation of secretion by cell positive regulation of hormone secretion positive regulation of secretion positive regulation of follicle-stimulating hormone secretion positive regulation of gonadotropin secretion positive regulation of transport cellular process involved in reproduction in multicellular organism luteinization lipid transport lipid export from cell ovulation cycle process steroid hormone secretion progesterone secretion ovulation cycle rhythmic process multicellular organismal reproductive process lipid localization macromolecule localization hemoglobin biosynthetic process hemoglobin metabolic process negative regulation of cell population proliferation cell population proliferation regulation of cell population proliferation regulation of cell cycle phase transition negative regulation of cell cycle cell cycle phase transition regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition mitotic cell cycle negative regulation of mitotic cell cycle regulation of mitotic cell cycle negative regulation of cell cycle phase transition cell cycle regulation of cell cycle cell cycle process negative regulation of G1/S transition of mitotic cell cycle negative regulation of mitotic cell cycle phase transition regulation of cell cycle process negative regulation of cell cycle G1/S phase transition negative regulation of cell cycle process regulation of mitotic cell cycle phase transition mitotic cell cycle process regulation of G1/S transition of mitotic cell cycle G1/S transition of mitotic cell cycle mitotic cell cycle phase transition mesodermal cell differentiation mesoderm morphogenesis tissue morphogenesis mesoderm formation mesoderm development ovulation sexual reproduction regulation of reproductive process female gamete generation gamete generation regulation of ovulation positive regulation of ovulation positive regulation of reproductive process positive regulation of transcription by RNA polymerase III transcription by RNA polymerase III regulation of transcription by RNA polymerase III eyelid development in camera-type eye sensory organ development eye development visual system development camera-type eye development sensory system development hematopoietic progenitor cell differentiation roof of mouth development cellular response to nitrogen compound response to angiotensin response to peptide hormone cellular response to peptide hormone stimulus cellular response to angiotensin response to nitrogen compound response to nutrient levels cellular response to nutrient levels cellular response to oxygen-glucose deprivation response to oxygen-glucose deprivation heart development cardiac fibroblast cell differentiation cardiocyte differentiation circulatory system development cardiac fibroblast cell development cardiac cell development ossification bone mineralization biomineral tissue development negative regulation of muscle cell differentiation regulation of striated muscle cell differentiation regulation of cardiac muscle cell differentiation muscle cell differentiation striated muscle tissue development muscle structure development negative regulation of cardiac muscle cell differentiation muscle tissue development negative regulation of cardiocyte differentiation cardiac muscle tissue development negative regulation of striated muscle cell differentiation cardiac muscle cell differentiation regulation of muscle cell differentiation regulation of cardiocyte differentiation striated muscle cell differentiation regulation of animal organ morphogenesis regulation of odontogenesis positive regulation of odontogenesis positive regulation of animal organ morphogenesis regulation of anatomical structure morphogenesis corticotropin hormone secreting cell differentiation endocrine system development pituitary gland development gland development diencephalon development adenohypophysis development positive regulation of cellular component organization positive regulation of extracellular matrix constituent secretion positive regulation of extracellular matrix organization extracellular matrix organization regulation of extracellular matrix constituent secretion extracellular structure organization extracellular matrix constituent secretion regulation of extracellular matrix organization external encapsulating structure organization regulation of biomineral tissue development regulation of bone mineralization positive regulation of ossification positive regulation of biomineral tissue development positive regulation of bone mineralization regulation of ossification mesenchyme morphogenesis endocardial cushion morphogenesis heart morphogenesis mesenchyme development endocardial cushion formation endocardial cushion development positive regulation of miRNA transcription positive regulation of miRNA metabolic process miRNA transcription regulation of miRNA metabolic process miRNA metabolic process regulation of miRNA transcription intracellular receptor signaling pathway positive regulation of peroxisome proliferator activated receptor signaling pathway peroxisome proliferator activated receptor signaling pathway regulation of peroxisome proliferator activated receptor signaling pathway nuclear receptor-mediated signaling pathway positive regulation of cell population proliferation positive regulation of osteoblast proliferation osteoblast proliferation regulation of osteoblast proliferation cell fate commitment anterior/posterior pattern specification pattern specification process regionalization embryonic heart tube anterior/posterior pattern specification connective tissue development skeletal system development chondrocyte differentiation cartilage development negative regulation of RNA biosynthetic process negative regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of RNA metabolic process Notch signaling pathway carbohydrate derivative metabolic process proteoglycan metabolic process glycoprotein metabolic process fat cell differentiation negative regulation of fat cell differentiation regulation of fat cell differentiation pericardium development muscle tissue morphogenesis cardiac muscle tissue morphogenesis muscle organ development muscle organ morphogenesis endodermal-mesodermal cell signaling regulation of epithelial to mesenchymal transition positive regulation of epithelial to mesenchymal transition epithelial to mesenchymal transition mesenchymal cell differentiation negative regulation of small molecule metabolic process regulation of hormone biosynthetic process regulation of lipid metabolic process negative regulation of lipid biosynthetic process negative regulation of hormone biosynthetic process regulation of small molecule metabolic process negative regulation of aldosterone biosynthetic process negative regulation of aldosterone metabolic process primary alcohol biosynthetic process hormone biosynthetic process negative regulation of steroid hormone biosynthetic process regulation of steroid hormone biosynthetic process negative regulation of steroid metabolic process regulation of alcohol biosynthetic process C21-steroid hormone biosynthetic process regulation of ketone metabolic process negative regulation of alcohol biosynthetic process regulation of aldosterone biosynthetic process negative regulation of hormone metabolic process negative regulation of lipid metabolic process regulation of steroid biosynthetic process mineralocorticoid biosynthetic process regulation of hormone metabolic process alcohol metabolic process C21-steroid hormone metabolic process aldehyde biosynthetic process mineralocorticoid metabolic process aldosterone metabolic process steroid hormone biosynthetic process aldosterone biosynthetic process regulation of ketone biosynthetic process regulation of steroid metabolic process aldehyde metabolic process regulation of aldosterone metabolic process alcohol biosynthetic process negative regulation of steroid biosynthetic process regulation of lipid biosynthetic process primary alcohol metabolic process cardiac atrium formation cardiac chamber morphogenesis cardiac atrium morphogenesis cardiac chamber formation cardiac atrium development cardiac chamber development thyroid-stimulating hormone-secreting cell differentiation neuroepithelial cell differentiation neuroendocrine cell differentiation glandular epithelial cell differentiation columnar/cuboidal epithelial cell differentiation telencephalon regionalization forebrain regionalization regulation of phosphatase activity regulation of catalytic activity positive regulation of phosphate metabolic process positive regulation of molecular function positive regulation of phosphatase activity positive regulation of phosphorus metabolic process positive regulation of dephosphorylation regulation of dephosphorylation dephosphorylation positive regulation of catalytic activity regulation of molecular function positive regulation of hydrolase activity regulation of hydrolase activity positive regulation of odontoblast differentiation regulation of epithelial cell differentiation odontoblast differentiation regulation of odontoblast differentiation positive regulation of epithelial cell differentiation positive regulation of neuroepithelial cell differentiation positive regulation of locomotion regulation of cell motility positive regulation of cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration cell migration cell motility locomotion p38MAPK cascade positive regulation of p38MAPK cascade regulation of p38MAPK cascade osteoclast differentiation inflammatory response cortisol metabolic process tertiary alcohol metabolic process glucocorticoid metabolic process glucocorticoid biosynthetic process regulation of cortisol biosynthetic process negative regulation of cortisol biosynthetic process regulation of glucocorticoid metabolic process regulation of glucocorticoid biosynthetic process negative regulation of glucocorticoid biosynthetic process negative regulation of glucocorticoid metabolic process cortisol biosynthetic process tertiary alcohol biosynthetic process ameloblast differentiation positive regulation of nervous system development astrocyte differentiation regulation of neurogenesis regulation of gliogenesis regulation of astrocyte differentiation positive regulation of gliogenesis regulation of nervous system development gliogenesis positive regulation of neurogenesis positive regulation of astrocyte differentiation positive regulation of cell development regulation of glial cell differentiation positive regulation of glial cell differentiation glial cell differentiation cellular response to BMP stimulus response to BMP cellular response to growth factor stimulus response to growth factor protein destabilization regulation of protein stability ear development inner ear development bone development regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway negative regulation of Wnt signaling pathway Wnt signaling pathway regulation of Wnt signaling pathway negative regulation of response to stimulus negative regulation of signal transduction negative regulation of canonical Wnt signaling pathway ureteric bud development mesonephric epithelium development kidney epithelium development mesenchymal cell proliferation involved in ureteric bud development mesonephros development tube development cell proliferation involved in kidney development renal system development mesenchymal cell proliferation cell proliferation involved in mesonephros development kidney development mesonephric tubule development embryo development ending in birth or egg hatching chordate embryonic development in utero embryonic development regulation of calcium-independent cell-cell adhesion regulation of cell adhesion negative regulation of cell adhesion cell adhesion cell-cell adhesion negative regulation of cell-cell adhesion calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules regulation of cell-cell adhesion negative regulation of calcium-independent cell-cell adhesion cell-cell adhesion via plasma-membrane adhesion molecules negative regulation of transforming growth factor beta receptor signaling pathway cellular response to transforming growth factor beta stimulus regulation of transforming growth factor beta receptor signaling pathway regulation of cellular response to transforming growth factor beta stimulus regulation of cellular response to growth factor stimulus response to transforming growth factor beta transforming growth factor beta receptor signaling pathway negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of Wnt signaling pathway cardiac epithelial to mesenchymal transition positive regulation of fat cell differentiation nephron morphogenesis branching morphogenesis of an epithelial tube nephron tubule morphogenesis nephron epithelium morphogenesis nephron tubule development ureteric bud morphogenesis tube morphogenesis branching involved in ureteric bud morphogenesis renal tubule development epithelial tube morphogenesis nephron development nephron epithelium development morphogenesis of an epithelium kidney morphogenesis morphogenesis of a branching structure mesonephric tubule morphogenesis renal tubule morphogenesis morphogenesis of a branching epithelium cardiac jelly development heart induction specification of animal organ identity developmental induction animal organ formation heart formation regulation of animal organ formation organ induction regulation of heart morphogenesis heart field specification regulation of odontogenesis of dentin-containing tooth odontogenesis of dentin-containing tooth regulation of cartilage development positive regulation of cartilage development osteoblast differentiation BMP signaling pathway regulation of smooth muscle cell proliferation smooth muscle cell proliferation negative regulation of smooth muscle cell proliferation muscle cell proliferation bone maturation regulation of bone mineralization involved in bone maturation positive regulation of bone mineralization involved in bone maturation ossification involved in bone maturation bone mineralization involved in bone maturation developmental maturation anatomical structure maturation animal organ maturation positive regulation of neuron differentiation regulation of neuron differentiation regulation of osteoblast differentiation positive regulation of osteoblast differentiation biological process involved in interspecies interaction between organisms response to other organism response to bacterium response to external stimulus response to external biotic stimulus response to biotic stimulus cell surface receptor protein tyrosine kinase signaling pathway regulation of insulin-like growth factor receptor signaling pathway insulin-like growth factor receptor signaling pathway negative regulation of insulin-like growth factor receptor signaling pathway positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein modification process positive regulation of protein phosphorylation protein modification process protein phosphorylation macromolecule modification heart valve development aortic valve development semi-lunar valve development atrioventricular canal morphogenesis atrioventricular canal development respiratory tube development vasculature development lung vasculature development lung development respiratory system development atrioventricular valve development heart valve morphogenesis atrioventricular valve morphogenesis	inhibin complex protein-containing complex inhibin A complex cellular anatomical structure extracellular region extracellular space enzyme activator complex intracellular anatomical structure perinuclear region of cytoplasm cytoplasm activin A complex activin complex cell periphery plasma membrane protein complex inhibin complex protein-containing complex inhibin A complex cellular anatomical structure extracellular region extracellular space enzyme activator complex intracellular anatomical structure perinuclear region of cytoplasm cytoplasm activin A complex activin complex cell periphery plasma membrane protein complex membrane plasma membrane plasma membrane signaling receptor complex membrane protein complex BMP receptor complex receptor complex cell surface membrane-bounded organelle intracellular organelle organelle intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR029034	Cystine-knot cytokine	Homologous Superfamily
A	IPR017948	Transforming growth factor beta, conserved site	Conserved Site
A	IPR001839	Transforming growth factor-beta, C-terminal	Domain
A	IPR015615	Transforming growth factor-beta-related	Family
A	IPR000491	Inhibin, beta A subunit	Family
A	IPR001111	TGF-beta, propeptide	Domain
A	IPR029034	Cystine-knot cytokine	Homologous Superfamily
A	IPR047953	Bone morphogenetic protein 2, TGF-beta-like domain	Domain
A	IPR017948	Transforming growth factor beta, conserved site	Conserved Site
A	IPR001839	Transforming growth factor-beta, C-terminal	Domain
A	IPR015615	Transforming growth factor-beta-related	Family
A	IPR001111	TGF-beta, propeptide	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P12643	uterine cancer acute liver failure preeclampsia uterine corpus leiomyoma ovarian adenocarcinoma leiomyoma ovarian cancer Pre-Eclampsia Sjogren syndrome breast cancer ductal breast carcinoma in situ interstitial cystitis lung adenocarcinoma malignant colon neoplasm nasopharyngeal carcinoma uterine cancer acute liver failure preeclampsia uterine corpus leiomyoma ovarian adenocarcinoma leiomyoma ovarian cancer Pre-Eclampsia Sjogren syndrome breast cancer ductal breast carcinoma in situ interstitial cystitis lung adenocarcinoma malignant colon neoplasm nasopharyngeal carcinoma pancreatic ductal adenocarcinoma tuberculosis adrenoleukodystrophy breast carcinoma gastric carcinoma invasive ductal breast carcinoma lung cancer malignant pancreatic neoplasm pilocytic astrocytoma psoriasis ulcerative colitis atrial fibrillation cystic fibrosis head and neck cancer lung carcinoma medulloblastoma craniosynostosis hereditary hemochromatosis brachydactyly type A2 20p12.3 microdeletion syndrome bone disease myopia uremia breast carcinoma colorectal cancer Fracture osteosarcoma gastric neoplasm peripheral arterial disease hemochromatosis type 1 interstitial cystitis short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies lung adenocarcinoma atopic eczema malignant colon neoplasm malignant mesothelioma non-small cell lung carcinoma ductal breast carcinoma in situ osteonecrosis ovarian cancer glioblastoma hereditary diffuse gastric adenocarcinoma psoriasis invasive ductal breast carcinoma spina bifida trigonocephaly lung cancer malignant ependymoma brachydactyly breast cancer colorectal adenoma Crohn disease oligodendroglioma esophageal adenocarcinoma osteoporosis gastric cancer pancreatic intraductal papillary-mucinous neoplasm pilocytic astrocytoma isolated right ventricular hypoplasia astrocytic tumor lung carcinoma bone fracture malignant glioma medulloblastoma nasopharyngeal carcinoma cutaneous lupus erythematosus osteoarthritis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.