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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Structure Author = "Cook, A."

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Search Summary

This query matches 16 Structures.

Refinements

Structure Determination Methodology

experimental (16)

Scientific Name of Source Organism

	Homo sapiens (11)
	Bos taurus (4)
	Mus musculus (4)
	Naegleria gruberi (2)
	Saccharomyces cerevisiae (1)
	synthetic construct (1)

Taxonomy

	Eukaryota (16)
	other sequences (1)

Experimental Method

	ELECTRON MICROSCOPY (8)
	X-RAY DIFFRACTION (8)

Polymer Entity Type

Protein (16)

Refinement Resolution (Å)

	1.5 - 2.0 (4)
	2.0 - 2.5 (2)
	2.5 - 3.0 (1)
	3.0 - 3.5 (1)
	3.5 - 4.0 (4)
	4.0 - 4.5 (1)
	> 4.5 (3)

Release Date

	2000 - 2004 (4)
	2005 - 2009 (2)
	2010 - 2014 (2)
	2015 - 2019 (8)

Enzyme Classification Name

	Hydrolases (8)
	Transferases (3)

Symmetry Type

	Asymmetric (13)
	Dihedral (3)

SCOP Classification

	All beta proteins (4)
	All alpha proteins (4)
	Artifacts (3)
	Alpha and beta proteins (a+b) (2)

AllSelected

1 to 16 of 16 Structures

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1E3F \| pdb_00001e3f	Download File View File

Structure of human transthyretin complexed with bromophenols: a new mode of binding

Ghosh, M., Meerts, I.A.T.M., Cook, A., Bergman, A., Brouwer, A., Johnson, L.N.

(2000) Acta Crystallogr D Biol Crystallogr 56: 1085

Released	2000-08-29
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	TRANSTHYRETIN (protein)

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1E4H \| pdb_00001e4h	Download File View File

Structure of human transthyretin complexed with bromophenols: a new mode of binding

Ghosh, M., Meerts, I.A.T.M., Cook, A., Bergman, A., Brouwer, A., Johnson, L.N.

(2000) Acta Crystallogr D Biol Crystallogr 56: 1085

Released	2000-08-29
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	TRANSTHYRETIN (protein)
Unique Ligands	GOL, PBR

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1E5A \| pdb_00001e5a	Download File View File

Structure of human transthyretin complexed with bromophenols: a new mode of binding

Ghosh, M., Meerts, I.A.T.M., Cook, A., Bergman, A., Brouwer, A., Johnson, L.N.

(2000) Acta Crystallogr D Biol Crystallogr 56: 1085

Released	2000-08-29
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	TRANSTHYRETIN (protein)
Unique Ligands	TBP

Explore in 3D

1GY3 \| pdb_00001gy3	Download File View File

pCDK2/cyclin A in complex with MgADP, nitrate and peptide substrate

Cook, A., Lowe, E.D., Chrysina, E.D., Skamnaki, V.T., Oikonomakos, N.G., Johnson, L.N.

(2002) Biochemistry 41: 7301

Released	2002-04-29
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Homo sapiens synthetic construct
Macromolecule	CELL DIVISION PROTEIN KINASE 2 (protein) CYCLIN A2 (protein) SUBSTRATE PEPTIDE (protein)
Unique Ligands	ATP, GOL, MG, NO3

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1W98 \| pdb_00001w98	Download File View File

The structural basis of CDK2 activation by cyclin E

Lowe, E.D., Honda, R., Dubinina, E., Skamnaki, V., Cook, A., Johnson, L.N.

(2005) EMBO J 24: 452

Released	2005-02-02
Method	X-RAY DIFFRACTION 2.15 Å
Organisms	Homo sapiens
Macromolecule	CELL DIVISION PROTEIN KINASE 2 (protein) G1/S-SPECIFIC CYCLIN E1 (protein)

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1Z3H \| pdb_00001z3h	Download File View File

The exportin Cse1 in its cargo-free, cytoplasmic state

Cook, A., Fernandez, E., Lindner, D., Ebert, J., Schlenstedt, G., Conti, E.

(2005) Mol Cell 18: 355-367

Released	2005-05-10
Method	X-RAY DIFFRACTION 3.1 Å
Organisms	Saccharomyces cerevisiae
Macromolecule	Importin alpha re-exporter (protein)
Unique Ligands	MG

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4E47 \| pdb_00004e47	Download File View File

SET7/9 in complex with inhibitor (R)-(3-(3-cyanophenyl)-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6- sulfonamide and S-adenosylmethionine

Walker, J.R., Ouyang, H., Dong, A., Fish, P., Cook, A., Barsyte, D., Vedadi, M., Tatlock, J., Owen, D., Bunnage, M., Bountra, C., Weigelt, J., Edwards, A.M., Arrowsmith, C.H., Brown, P.J., Structural Genomics Consortium (SGC)

To be published

Released	2012-03-28
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Histone-lysine N-methyltransferase SETD7 (protein)
Unique Ligands	0N6, BME, SAM, SO4

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4E96 \| pdb_00004e96	Download File View File

Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor PFi-1

Filippakopoulos, P., Picaud, S., Felletar, I., Fedorov, O., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Fish, P., Bunnage, M., Owen, D., Knapp, S., Cook, A., Structural Genomics Consortium (SGC)

(2012) J Med Chem 55: 9831-9837

Released	2012-04-18
Method	X-RAY DIFFRACTION 1.92 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain-containing protein 4 (protein)
Unique Ligands	0NS, DMS, EDO, NA

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5ND2 \| pdb_00005nd2	Download File View File

Microtubule-bound MKLP2 motor domain in the presence of ADP

Atherton, J., Yu, I.M., Cook, A., Muretta, J.M., Joseph, A.P., Major, J., Sourigues, Y., Clause, J., Topf, M., Rosenfeld, S.S., Houdusse, A., Moores, C.A.

(2017) Elife 6:

Released	2017-10-04
Method	ELECTRON MICROSCOPY 5.8 Å
Organisms	Bos taurus Mus musculus
Macromolecule	Kinesin-like protein KIF20A (protein) Tubulin alpha chain (protein) Tubulin beta-2B chain (protein)
Unique Ligands	ADP, GDP, GTP, MG, TA1

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5ND3 \| pdb_00005nd3	Download File View File

Microtubule-bound MKLP2 motor domain in the with no nucleotide

Atherton, J., Yu, I.M., Cook, A., Muretta, J.M., Joseph, A.P., Major, J., Sourigues, Y., Clause, J., Topf, M., Rosenfeld, S.S., Houdusse, A., Moores, C.A.

(2017) Elife 6:

Released	2017-10-04
Method	ELECTRON MICROSCOPY 6.1 Å
Organisms	Bos taurus Mus musculus
Macromolecule	Kinesin-like protein KIF20A (protein) Tubulin alpha chain (protein) Tubulin beta-2B chain (protein)
Unique Ligands	GDP, GTP, MG, TA1

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5ND4 \| pdb_00005nd4	Download File View File

Microtubule-bound MKLP2 motor domain in the presence of ADP.AlFx

Atherton, J., Yu, I.-M., Cook, A., Muretta, J.M., Joseph, A.P., Major, J., Sourigues, Y., Clause, J., Topf, M., Rosenfeld, S.S., Houdusse, A., Moores, C.A.

(2017) Elife 6:

Released	2017-10-04
Method	ELECTRON MICROSCOPY 4.4 Å
Organisms	Bos taurus Mus musculus
Macromolecule	Kinesin-like protein KIF20A (protein) Tubulin alpha chain (protein) Tubulin beta-2B chain (protein)
Unique Ligands	ADP, ALF, GDP, GTP, MG, TA1

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5ND7 \| pdb_00005nd7	Download File View File

Microtubule-bound MKLP2 motor domain in the presence of AMPPNP

Atherton, J., Yu, I.-M., Cook, A., Muretta, J.M., Joseph, A.P., Major, J., Sourigues, Y., Clause, J., Topf, M., Rosenfeld, S.S., Houdusse, A., Moores, C.A.

(2017) Elife 6:

Released	2017-10-04
Method	ELECTRON MICROSCOPY 7.9 Å
Organisms	Bos taurus Mus musculus
Macromolecule	Kinesin-like protein KIF20A (protein) Tubulin alpha chain (protein) Tubulin beta-2B chain (protein)
Unique Ligands	ANP, GDP, GTP, MG, TA1

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6QUS \| pdb_00006qus	Download File View File

HsCKK (human CAMSAP1) decorated 13pf taxol-GDP microtubule

Atherton, J.M., Luo, Y., Xiang, S., Yang, C., Jiang, K., Stangier, M., Vemu, A., Cook, A., Wang, S., Roll-Mecak, A., Steinmetz, M.O., Akhmanova, A., Baldus, M., Moores, C.A.

(2019) Nat Commun 10: 5236-5236

Released	2019-11-27
Method	ELECTRON MICROSCOPY 3.7 Å
Organisms	Homo sapiens
Macromolecule	Calmodulin-regulated spectrin-associated protein 1 (protein) Tubulin alpha-1B chain (protein) Tubulin beta chain (protein)
Unique Ligands	GDP, GTP, MG, TA1

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6QUY \| pdb_00006quy	Download File View File

NgCKK (N.Gruberi CKK) decorated 13pf taxol-GDP microtubule

Atherton, J.M., Luo, Y., Xiang, S., Yang, C., Jiang, K., Stangier, M., Vemu, A., Cook, A., Wang, S., Roll-Mecak, A., Steinmetz, M.O., Akhmanova, A., Baldus, M., Moores, C.A.

(2019) Nat Commun 10: 5236-5236

Released	2019-11-27
Method	ELECTRON MICROSCOPY 3.8 Å
Organisms	Homo sapiens Naegleria gruberi
Macromolecule	CKK domain protein (protein) Tubulin alpha-1B chain (protein) Tubulin beta chain (protein)
Unique Ligands	GDP, GTP, MG, TA1

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6QVE \| pdb_00006qve	Download File View File

NgCKK (Naegleria Gruberi CKK) decorated 14pf taxol-GDP microtubule

Atherton, J.M., Luo, Y., Xiang, S., Yang, C., Jiang, K., Stangier, M., Vemu, A., Cook, A., Wang, S., Roll-Mecak, A., Steinmetz, M.O., Akhmanova, A., Baldus, M., Moores, C.A.

(2019) Nat Commun 10: 5236-5236

Released	2019-11-27
Method	ELECTRON MICROSCOPY 3.7 Å
Organisms	Homo sapiens Naegleria gruberi
Macromolecule	Beta1-tubulin (protein) Predicted protein (protein) Tubulin alpha-1B chain (protein)
Unique Ligands	GDP, GTP, MG, TA1

Explore in 3D

6QVJ \| pdb_00006qvj	Download File View File

HsCKK (human CAMSAP1) decorated 14pf taxol-GDP microtubule

Atherton, J.M., Luo, Y., Xiang, S., Yang, C., Jiang, K., Stangier, M., Vemu, A., Cook, A., Wang, S., Roll-Mecak, A., Steinmetz, M.O., Akhmanova, A., Baldus, M., Moores, C.A.

(2019) Nat Commun 10: 5236-5236

Released	2019-11-27
Method	ELECTRON MICROSCOPY 3.8 Å
Organisms	Homo sapiens
Macromolecule	Calmodulin-regulated spectrin-associated protein 1 (protein) Tubulin alpha-1B chain (protein) Tubulin beta chain (protein)
Unique Ligands	GDP, GTP, MG, TA1

1 to 16 of 16 Structures

Page 1 of 1

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RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

1E3F | pdb_00001e3f

Structure of human transthyretin complexed with bromophenols: a new mode of binding

1E4H | pdb_00001e4h

Structure of human transthyretin complexed with bromophenols: a new mode of binding

1E5A | pdb_00001e5a

Structure of human transthyretin complexed with bromophenols: a new mode of binding

1GY3 | pdb_00001gy3

pCDK2/cyclin A in complex with MgADP, nitrate and peptide substrate

1W98 | pdb_00001w98

The structural basis of CDK2 activation by cyclin E

1Z3H | pdb_00001z3h

The exportin Cse1 in its cargo-free, cytoplasmic state

4E47 | pdb_00004e47

SET7/9 in complex with inhibitor (R)-(3-(3-cyanophenyl)-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6- sulfonamide and S-adenosylmethionine

4E96 | pdb_00004e96

Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor PFi-1

5ND2 | pdb_00005nd2

Microtubule-bound MKLP2 motor domain in the presence of ADP

5ND3 | pdb_00005nd3

Microtubule-bound MKLP2 motor domain in the with no nucleotide

5ND4 | pdb_00005nd4

Microtubule-bound MKLP2 motor domain in the presence of ADP.AlFx

5ND7 | pdb_00005nd7

Microtubule-bound MKLP2 motor domain in the presence of AMPPNP

6QUS | pdb_00006qus

HsCKK (human CAMSAP1) decorated 13pf taxol-GDP microtubule

6QUY | pdb_00006quy

NgCKK (N.Gruberi CKK) decorated 13pf taxol-GDP microtubule

6QVE | pdb_00006qve

NgCKK (Naegleria Gruberi CKK) decorated 14pf taxol-GDP microtubule

6QVJ | pdb_00006qvj

HsCKK (human CAMSAP1) decorated 14pf taxol-GDP microtubule

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

1E3F | pdb_00001e3f

1E4H | pdb_00001e4h

1E5A | pdb_00001e5a

1GY3 | pdb_00001gy3

1W98 | pdb_00001w98

1Z3H | pdb_00001z3h

4E47 | pdb_00004e47

4E96 | pdb_00004e96

5ND2 | pdb_00005nd2

5ND3 | pdb_00005nd3

5ND4 | pdb_00005nd4

5ND7 | pdb_00005nd7

6QUS | pdb_00006qus

6QUY | pdb_00006quy

6QVE | pdb_00006qve

6QVJ | pdb_00006qvj