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234,136 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Structure Author = "Hanoulle, X."

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Search Summary

This query matches 24 Structures.

Refinements

Structure Determination Methodology

experimental (24)

Scientific Name of Source Organism

	Severe acute respiratory syndrome coronavirus 2 (13)
	Homo sapiens (6)
	Lama glama (5)
	Chlorocebus aethiops (1)
	Escherichia coli (1)
	Hepacivirus hominis (1)
	Hepatitis C virus (isolate Con1) (1)
	Paslahepevirus balayani (1)
	Tolypocladium inflatum (1)

Taxonomy

	Riboviria (16)
	Eukaryota (8)
	Bacteria (1)

Experimental Method

	X-RAY DIFFRACTION (21)
	SOLUTION NMR (3)

Polymer Entity Type

Protein (24)

Refinement Resolution (Å)

	1.0 - 1.5 (5)
	1.5 - 2.0 (13)
	2.0 - 2.5 (2)
	2.5 - 3.0 (1)

Release Date

	2000 - 2004 (1)
	2010 - 2014 (1)
	2015 - 2019 (3)
	2020 - 2024 (18)
	2025 - 2029 (1)

Enzyme Classification Name

	Hydrolases (13)
	Transferases (1)
	Isomerases (1)

Membrane Protein Annotation

OPM (1)

Symmetry Type

	Cyclic (15)
	Asymmetric (10)

SCOP Classification

	All beta proteins (1)
	Artifacts (1)

AllSelected

1 to 24 of 24 Structures

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1TXK \| pdb_00001txk	Download File View File

Crystal structure of Escherichia coli OpgG

Hanoulle, X., Rollet, E., Clantin, B., Landrieu, I., Odberg-Ferragut, C., Lippens, G., Bohin, J.P., Villeret, V.

(2004) J Mol Biology 342: 195-205

Released	2004-09-07
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Escherichia coli
Macromolecule	Glucans biosynthesis protein G (protein)
Unique Ligands	NA

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2M5L \| pdb_00002m5l	Download File View File

Ns5a308

Montserret, R., Badillo, A., Hanoulle, X., Lippens, G., Penin, F.

To be published

Released	2014-03-05
Method	SOLUTION NMR
Organisms	Hepatitis C virus (isolate Con1)
Macromolecule	NS5A protein (protein)

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5HSV \| pdb_00005hsv	Download File View File

X-Ray structure of a CypA-Alisporivir complex at 1.5 angstrom resolution

Dujardin, M., Bouckaert, J., Rucktooa, P., Hanoulle, X.

(2018) Acta Crystallogr F Struct Biol Commun 74: 583-592

Released	2017-08-16
Method	X-RAY DIFFRACTION 1.5 Å
Organisms	Chlorocebus aethiops Tolypocladium inflatum
Macromolecule	Alisporivir (protein) Peptidyl-prolyl cis-trans isomerase A (protein)
Unique Ligands	CL

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5ODD \| pdb_00005odd	Download File View File

HUMAN MED26 N-TERMINAL DOMAIN (1-92)

Lens, Z., Cantrelle, F.-X., Perruzini, R., Dewitte, F., Hanoulle, X., Villeret, V., Verger, A., Landrieu, I.

(2016) Biomol NMR Assign 10: 233-236

Released	2017-11-29
Method	SOLUTION NMR
Organisms	Homo sapiens
Macromolecule	Mediator of RNA polymerase II transcription subunit 26 (protein)

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6HT4 \| pdb_00006ht4	Download File View File

NMR Structure of NS5A-D2 (JFH1) peptide (304-323)

Dujardin, M., Cantrelle, F.X., Lippens, G., Hanoulle, X.

(2019) J Biological Chem 294: 13171-13185

Released	2019-07-24
Method	SOLUTION NMR
Organisms	Hepacivirus hominis
Macromolecule	NS5A (protein)

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7NLC \| pdb_00007nlc	Download File View File

Crystallographic structure of human Tsg101 UEV domain in complex with a HEV ORF3 peptide

Moschidi, D., Dupre, E., Villeret, V., Hanoulle, X.

To be published

Released	2022-03-02
Method	X-RAY DIFFRACTION 1.398 Å
Organisms	Homo sapiens Paslahepevirus balayani
Macromolecule	Protein ORF3 (protein) Tsg101 UEV domain (protein)
Unique Ligands	CL, NH4, SO4

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7NTQ \| pdb_00007ntq	Download File View File

Crystal structure of the SARS-CoV-2 Main Protease complexed with N-(pyridin-3-ylmethyl)thioformamide

Dupre, E., Villeret, V., Hanoulle, X.

(2023) Eur J Med Chem 250: 115186-115186

Released	2022-03-02
Method	X-RAY DIFFRACTION 1.495 Å
Organisms	Severe acute respiratory syndrome coronavirus 2
Macromolecule	3C-like proteinase (protein)
Unique Ligands	35J, DMS, FMT, NA

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7NTS \| pdb_00007nts	Download File View File

Crystal structure of the SARS-CoV-2 Main Protease with oxidized C145

Dupre, E., Villeret, V., Hanoulle, X.

(2021) Angew Chem Int Ed Engl 60: 25428-25435

Released	2021-10-06
Method	X-RAY DIFFRACTION 1.477 Å
Organisms	Severe acute respiratory syndrome coronavirus 2
Macromolecule	Replicase polyprotein 1ab (protein)
Unique Ligands	DMS, FMT, GOL

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7NTT \| pdb_00007ntt	Download File View File

Crystal structure of the SARS-CoV-2 Main Protease

Dupre, E., Villeret, V., Hanoulle, X.

To be published

Released	2022-03-02
Method	X-RAY DIFFRACTION 1.743 Å
Organisms	Severe acute respiratory syndrome coronavirus 2
Macromolecule	3C-like proteinase (protein)
Unique Ligands	FMT, NA

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7NTW \| pdb_00007ntw	Download File View File

Crystal structure of the SARS-CoV-2 Main Protease with a Zinc ion coordinated in the active site

Dupre, E., Villeret, V., Hanoulle, X.

To be published

Released	2022-03-02
Method	X-RAY DIFFRACTION 1.815 Å
Organisms	Severe acute respiratory syndrome coronavirus 2
Macromolecule	3C-like proteinase (protein)
Unique Ligands	DMS, FMT, NA, ZN

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7P51 \| pdb_00007p51	Download File View File

CRYSTAL STRUCTURE OF THE SARS-COV-2 MAIN PROTEASE COMPLEXED WITH FRAGMENT F01

Hanoulle, X., Moschidi, D.

(2021) Angew Chem Int Ed Engl 60: 25428-25435

Released	2021-10-06
Method	X-RAY DIFFRACTION 1.474 Å
Organisms	Severe acute respiratory syndrome coronavirus 2
Macromolecule	3C-like proteinase (protein)
Unique Ligands	5P9, DMS, NA

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7QCQ \| pdb_00007qcq	Download File View File

VHH Z70 in interaction with PHF6 Tau peptide

Danis, C., Dupre, E., Zejneli, O., Caillierez, R., Arrial, A., Begard, S., Loyens, A., Mortelecque, J., Cantrelle, F.-X., Hanoulle, X., Rain, J.-C., Colin, M., Buee, L., Landrieu, I.

(2022) Mol Ther 30: 1484-1499

Released	2021-12-08
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Lama glama
Macromolecule	Tau 301-312 (protein) VHH Z70 (protein)
Unique Ligands	GOL

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8AEB \| pdb_00008aeb	Download File View File

SARS-CoV-2 Main Protease complexed with N-(pyridin-3-ylmethyl)thioformamide

Hanoulle, X., Charton, J., Deprez, B.

(2023) Eur J Med Chem 250: 115186-115186

Released	2023-03-15
Method	X-RAY DIFFRACTION 1.83 Å
Organisms	Severe acute respiratory syndrome coronavirus 2
Macromolecule	3C-like proteinase nsp5 (protein)
Unique Ligands	35J, DMS, NA

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8OP0 \| pdb_00008op0	Download File View File

VHH Z70 mutant 20 in interaction with PHF6 Tau peptide

Dupre, E., Mortelecque, J., NGuyen, M., Hanoulle, X., Landrieu, I.

(2024) J Biological Chem 300: 107163-107163

Released	2023-05-31
Method	X-RAY DIFFRACTION 1.54 Å
Organisms	Homo sapiens Lama glama
Macromolecule	Tau PHF6 peptide (protein) VHH Z70 mutant 20 (protein)

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8OPI \| pdb_00008opi	Download File View File

VHH Z70 mutant 1 in interaction with PHF6 Tau peptide

Dupre, E., Mortelecque, J., NGuyen, M., Hanoulle, X., Landrieu, I.

(2024) J Biological Chem 300: 107163-107163

Released	2023-05-31
Method	X-RAY DIFFRACTION 1.83 Å
Organisms	Homo sapiens Lama glama
Macromolecule	PHF6 Tau peptide (protein) VHH Z70 mutant 1 (protein)

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8PII \| pdb_00008pii	Download File View File

VHH Z70 mutant 3 in interaction with PHF6 Tau peptide

Dupre, E., Mortelecque, J., NGuyen, M., Hanoulle, X., Landrieu, I.

(2024) J Biological Chem 300: 107163-107163

Released	2023-07-05
Method	X-RAY DIFFRACTION 2.35 Å
Organisms	Homo sapiens Lama glama
Macromolecule	Microtubule-associated protein tau (protein) VHH Z70 Mutant 3 (protein)

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8RI4 \| pdb_00008ri4	Download File View File

Crystal structure of the SARS-CoV-2 Main Protease inhibited by (2-methylsulfanyl-6,7-dihydro-[1,4]dioxino[2,3-f]benzimidazol-3-yl)-(p-tolyl)methanone

Charton, J., Deprez, B., Hanoulle, X.

To be published

Released	2025-01-01
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Severe acute respiratory syndrome coronavirus 2
Macromolecule	3C-like proteinase nsp5 (protein)
Unique Ligands	4MA, DMS, FMT, GOL, NA

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9G13 \| pdb_00009g13	Download File View File

VHH H3-2 in complex with Tau C-terminal peptide

Dupre, E., Landrieu, I., Danis, C., Hanoulle, X., Mortelecque, J.

To be published

Released	2024-07-31
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens Lama glama
Macromolecule	Isoform Tau-F of Microtubule-associated protein tau (protein) VHH H3-2 (protein)

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9HBQ \| pdb_00009hbq	Download File View File

SARS-CoV-2 Main Protease complexed with (1R)-N-(3-chlorophenyl)-3-oxo-indane-1-carboxamide

Hanoulle, X., Charton, J., Deprez, B.

To be published

Released	2024-11-27
Method	X-RAY DIFFRACTION 1.795 Å
Organisms	Severe acute respiratory syndrome coronavirus 2
Macromolecule	3C-like proteinase nsp5 (protein)
Unique Ligands	A1ITO, DMS, GOL

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9HC1 \| pdb_00009hc1	Download File View File

SARS-CoV-2 Main Protease complexed with (1R)-N-(3-chlorophenyl)-3-oxo-N-[4-(2-oxopyrrolidin-1-yl)phenyl]indane-1-carboxamide

Hanoulle, X., Charton, J., Deprez, B.

To be published

Released	2024-11-27
Method	X-RAY DIFFRACTION 1.493 Å
Organisms	Severe acute respiratory syndrome coronavirus 2
Macromolecule	3C-like proteinase nsp5 (protein)
Unique Ligands	A1ITP, DMS, GOL, NA

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9HD8 \| pdb_00009hd8	Download File View File

SARS-CoV-2 Main Protease in complex with with (1R)-N-(3-chlorophenyl)-N-[4-(2,4-dioxo-1H-pyrimidin-5-yl)phenyl]-3-oxo-indane-1-carboxamide

Hanoulle, X., Charton, J., Deprez, B.

To be published

Released	2024-11-27
Method	X-RAY DIFFRACTION 1.696 Å
Organisms	Severe acute respiratory syndrome coronavirus 2
Macromolecule	3C-like proteinase nsp5 (protein)
Unique Ligands	A1ITV, NA

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9HDC \| pdb_00009hdc	Download File View File

SARS-CoV-2 Main Protease in complex with (3S)-3-[(3R)-3-phenylpiperidine-1-carbonyl]indan-1-one

Hanoulle, X., Charton, J., Deprez, B.

To be published

Released	2024-11-27
Method	X-RAY DIFFRACTION 1.794 Å
Organisms	Severe acute respiratory syndrome coronavirus 2
Macromolecule	3C-like proteinase nsp5 (protein)
Unique Ligands	A1ITW, DMS, FMT

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9HDJ \| pdb_00009hdj	Download File View File

SARS-CoV-2 Main Protease in complex with (3R)-3-[(3R)-4-benzyl-3-phenyl-piperidine-1-carbonyl]indan-1-one

Hanoulle, X., Charton, J., Deprez, B.

To be published

Released	2024-11-27
Method	X-RAY DIFFRACTION 2.05 Å
Organisms	Severe acute respiratory syndrome coronavirus 2
Macromolecule	3C-like proteinase nsp5 (protein)
Unique Ligands	A1IT1, FMT

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9HDN \| pdb_00009hdn	Download File View File

SARS-CoV-2 Main Protease in complex with (1R)-3-oxo-N-[2-oxo-2-(N-phenylanilino)ethyl]indane-1-carboxamide

Hanoulle, X., Charton, J., Deprez, B.

To be published

Released	2024-11-27
Method	X-RAY DIFFRACTION 1.77 Å
Organisms	Severe acute respiratory syndrome coronavirus 2
Macromolecule	3C-like proteinase nsp5 (protein)
Unique Ligands	A1IT2

1 to 24 of 24 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Membrane Protein Annotation

Symmetry Type

SCOP Classification

1TXK | pdb_00001txk

2M5L | pdb_00002m5l

5HSV | pdb_00005hsv

5ODD | pdb_00005odd

6HT4 | pdb_00006ht4

7NLC | pdb_00007nlc

7NTQ | pdb_00007ntq

7NTS | pdb_00007nts

7NTT | pdb_00007ntt

7NTW | pdb_00007ntw

7P51 | pdb_00007p51

7QCQ | pdb_00007qcq

8AEB | pdb_00008aeb

8OP0 | pdb_00008op0

8OPI | pdb_00008opi

8PII | pdb_00008pii

8RI4 | pdb_00008ri4

9G13 | pdb_00009g13

9HBQ | pdb_00009hbq

9HC1 | pdb_00009hc1

9HD8 | pdb_00009hd8

9HDC | pdb_00009hdc

9HDJ | pdb_00009hdj

9HDN | pdb_00009hdn