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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Citation Author = "Rose, M."

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Search Summary

This query matches 23 Structures.

Refinements

Structure Determination Methodology

experimental (23)

Scientific Name of Source Organism

	Homo sapiens (17)
	Nicotiana plumbaginifolia (2)
	Nicotiana tabacum (2)
	Staphylococcus hominis (2)
	Bacillus subtilis subsp. subtilis str. 168 (1)
	Stichodactyla helianthus (1)
	unidentified (1)

Taxonomy

	Eukaryota (20)
	Eukaryota (eukaryotes) (5)
	Bacteria (3)
	unclassified sequences (1)

Experimental Method

X-RAY DIFFRACTION (23)

Polymer Entity Type

Protein (23)

Refinement Resolution (Å)

	1.0 - 1.5 (6)
	1.5 - 2.0 (3)
	2.0 - 2.5 (9)
	2.5 - 3.0 (2)
	3.0 - 3.5 (3)

Release Date

	2005 - 2009 (1)
	2010 - 2014 (9)
	2015 - 2019 (8)
	2020 - 2024 (5)

Enzyme Classification Name

	Transferases (15)
	Hydrolases (2)
	Translocases (2)
	Lyases (1)

Symmetry Type

	Cyclic (13)
	Asymmetric (10)

SCOP Classification

	All alpha proteins (7)
	Artifacts (6)
	Alpha and beta proteins (a/b) (3)
	Alpha and beta proteins (a+b) (6)

AllSelected

1 to 23 of 23 Structures

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3CU8 \| pdb_00003cu8	Download File View File

Impaired binding of 14-3-3 to Raf1 is linked to Noonan and LEOPARD syndrome

Schumacher, B., Weyand, M., Kuhlmann, J., Ottmann, C.

(2010) Mol Cell Biol 30: 4698-4711

Released	2009-05-05
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	14-3-3 protein zeta/delta (protein) RAF proto-oncogene serine/threonine-protein kinase (protein)
Unique Ligands	MG, PPI

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3IQJ \| pdb_00003iqj	Download File View File

Crystal Structure of human 14-3-3 sigma in Complex with Raf1 peptide (10mer)

Ottmann, C., Weyand, M.

(2010) Mol Cell Biol 30: 4698-4711

Released	2010-09-01
Method	X-RAY DIFFRACTION 1.15 Å
Organisms	Homo sapiens
Macromolecule	10-mer peptide from RAF proto-oncogene serine/threonine-protein kinase (protein) 14-3-3 protein sigma (protein)
Unique Ligands	CL, MG

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3IQU \| pdb_00003iqu	Download File View File

Crystal Structure of human 14-3-3 sigma in Complex with Raf1 peptide (6mer)

Ottmann, C., Weyand, M.

(2010) Mol Cell Biol 30: 4698-4711

Released	2010-09-01
Method	X-RAY DIFFRACTION 1.05 Å
Organisms	Homo sapiens
Macromolecule	14-3-3 protein sigma (protein) 6-mer from RAF proto-oncogene serine/threonine-protein kinase (protein)
Unique Ligands	CL, MG

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3IQV \| pdb_00003iqv	Download File View File

Crystal Structure of human 14-3-3 sigma in Complex with Raf1 peptide (6mer) and stabilisator Fusicoccin

Ottmann, C., Weyand, M.

(2010) Mol Cell Biol 30: 4698-4711

Released	2010-09-01
Method	X-RAY DIFFRACTION 1.2 Å
Organisms	Homo sapiens
Macromolecule	14-3-3 protein sigma (protein) 6-mer peptide from RAF proto-oncogene serine/threonine-protein kinase (protein)
Unique Ligands	CL, FSC, MG

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3M50 \| pdb_00003m50	Download File View File

Structure of the 14-3-3/PMA2 complex stabilized by Epibestatin

Ottmann, C., Rose, R., Waldmann, H.

(2010) Angew Chem Int Ed Engl 49: 4129-4132

Released	2010-05-26
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Nicotiana plumbaginifolia Nicotiana tabacum
Macromolecule	14-3-3-like protein C (protein) N.plumbaginifolia H+-translocating ATPase mRNA (protein)
Unique Ligands	EBT

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3M51 \| pdb_00003m51	Download File View File

Structure of the 14-3-3/PMA2 complex stabilized by Pyrrolidone1

Ottmann, C., Rose, R., Waldmann, H.

(2010) Angew Chem Int Ed Engl 49: 4129-4132

Released	2010-05-26
Method	X-RAY DIFFRACTION 3.25 Å
Organisms	Nicotiana plumbaginifolia Nicotiana tabacum
Macromolecule	14-3-3-like protein C (protein) N.plumbaginifolia H+-translocating ATPase mRNA (protein)
Unique Ligands	YR1

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3NKX \| pdb_00003nkx	Download File View File

Impaired binding of 14-3-3 to Raf1 is linked to Noonan and LEOPARD syndrome

Schumacher, B., Weyand, M., Ottmann, C.

(2010) Mol Cell Biol 30: 4698-4711

Released	2010-09-15
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	14-3-3 protein zeta/delta (protein) Peptide of RAF proto-oncogene serine/threonine-protein kinase (protein)
Unique Ligands	PPI

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3O8I \| pdb_00003o8i	Download File View File

Structure of 14-3-3 isoform sigma in complex with a C-Raf1 peptide and a stabilizing small molecule fragment

Ottmann, C., Rose, R., Kaiser, M., Kuhenne, P.

(2010) Mol Cell Biol 30: 4698-4711

Released	2010-09-29
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	14-3-3 binding site peptide of RAF proto-oncogene serine/threonine-protein kinase (protein) 14-3-3 protein sigma (protein)
Unique Ligands	M1T

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4DAT \| pdb_00004dat	Download File View File

Structure of 14-3-3 sigma in complex with PADI6 14-3-3 binding motif II

Rose, R., Rose, M., Ottmann, C.

(2012) J Struct Biol 180: 65-72

Released	2012-06-13
Method	X-RAY DIFFRACTION 1.4 Å
Organisms	Homo sapiens
Macromolecule	14-3-3 protein sigma (protein) Peptidylarginine Deiminase type VI (protein)
Unique Ligands	MG

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4DAU \| pdb_00004dau	Download File View File

Structure of 14-3-3 sigma in complex with PADI6 14-3-3 binding motif I

Rose, R., Rose, M., Ottmann, C.

(2012) J Struct Biol 180: 65-72

Released	2012-06-13
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	14-3-3 protein sigma (protein) Peptidylarginine Deiminase type VI (protein)

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4X7H \| pdb_00004x7h	Download File View File

Co-crystal Structure of PERK bound to N-{5-[(6,7-dimethoxyquinolin-4-yl)oxy]pyridin-2-yl}-1-methyl-3-oxo-2-phenyl-5-(pyridin-4-yl)-2,3-dihydro-1H-pyrazole-4-carboxamide inhibitor

Shaffer, P.L., Bellon, S.F., Long, A.M., Chen, H.

(2015) J Med Chem 58: 1426-1441

Released	2015-02-04
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Eukaryotic translation initiation factor 2-alpha kinase 3,Eukaryotic translation initiation factor 2-alpha kinase 3 (protein)
Unique Ligands	3Z2, SO4

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4X7J \| pdb_00004x7j	Download File View File

Co-crystal Structure of PERK with 2-amino-N-[4-methoxy-3-(trifluoromethyl)phenyl]-4-methyl-3-[2-(methylamino)quinazolin-6-yl]benzamide inhibitor

Shaffer, P.L., Long, A.M., Chen, H.

(2015) J Med Chem 58: 1426-1441

Released	2015-01-28
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	Eukaryotic translation initiation factor 2-alpha kinase 3,Eukaryotic translation initiation factor 2-alpha kinase 3 (protein)
Unique Ligands	3Z1, TLA

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4X7K \| pdb_00004x7k	Download File View File

Co-crystal Structure of PERK bound to 4-{2-amino-3-[5-fluoro-2-(methylamino)quinazolin-6-yl]-4-methylbenzoyl}-1-methyl-2,5-diphenyl-1,2-dihydro-3H-pyrazol-3-one inhibitor

Shaffer, P.L., Long, A.M., Chen, H.

(2015) J Med Chem 58: 1426-1441

Released	2015-01-28
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	Eukaryotic translation initiation factor 2-alpha kinase 3,Eukaryotic translation initiation factor 2-alpha kinase 3 (protein)
Unique Ligands	3Z3, GOL, TLA

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4X7L \| pdb_00004x7l	Download File View File

Co-crystal Structure of PERK bound to 4-{2-amino-4-methyl-3-[2-(methylamino)-1,3-benzothiazol-6-yl]benzoyl}-1-methyl-2,5-diphenyl-1,2-dihydro-3H-pyrazol-3-one inhibitor

Shaffer, P.L., Long, A.M., Chen, H.

(2015) J Med Chem 58: 1426-1441

Released	2015-01-28
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	Eukaryotic translation initiation factor 2-alpha kinase 3,Eukaryotic translation initiation factor 2-alpha kinase 3 (protein)
Unique Ligands	3Z4, GOL, TLA

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4X7N \| pdb_00004x7n	Download File View File

Co-crystal Structure of PERK bound to 4-[2-amino-4-methyl-3-(2-methylquinolin-6-yl)benzoyl]-1-methyl-2,5-diphenyl-1,2-dihydro-3H-pyrazol-3-one inhibitor

Shaffer, P.L., Long, A.M., Chen, H.

(2015) J Med Chem 58: 1426-1441

Released	2015-01-28
Method	X-RAY DIFFRACTION 2.35 Å
Organisms	Homo sapiens
Macromolecule	Eukaryotic translation initiation factor 2-alpha kinase 3,Eukaryotic translation initiation factor 2-alpha kinase 3 (protein)
Unique Ligands	3Z5, TLA

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4X7O \| pdb_00004x7o	Download File View File

Co-crystal Structure of PERK bound to 1-[5-(4-amino-2,7-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-[3-fluoro-5-(trifluoromethyl)phenyl]ethanone inhibitor

Shaffer, P.L., Long, A.M., Chen, H.

(2015) J Med Chem 58: 1426-1441

Released	2015-01-28
Method	X-RAY DIFFRACTION 2.65 Å
Organisms	Homo sapiens
Macromolecule	Eukaryotic translation initiation factor 2-alpha kinase 3,Eukaryotic translation initiation factor 2-alpha kinase 3 (protein)
Unique Ligands	3Z6

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4Z7P \| pdb_00004z7p	Download File View File

X-ray structure of racemic ShK Q16K toxin

Sickmier, E.A.

(2015) J Med Chem 58: 6784-6802

Released	2015-09-09
Method	X-RAY DIFFRACTION 1.2 Å
Organisms	Stichodactyla helianthus
Macromolecule	Potassium channel toxin kappa-stichotoxin-She1a (protein)
Unique Ligands	SO4

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6I3U \| pdb_00006i3u	Download File View File

Optimization of potent and selective ATM inhibitors suitable for a proof-of-concept study in Huntington's disease models

Leonard, P.M.

(2019) J Med Chem 62: 2988-3008

Released	2019-03-20
Method	X-RAY DIFFRACTION 2.09 Å
Organisms	Homo sapiens
Macromolecule	Phosphatidylinositol 3-kinase catalytic subunit type 3 (protein)
Unique Ligands	H2E

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6QP1 \| pdb_00006qp1	Download File View File

Crystal structure of the PLP-bound C-S lyase in the external aldimine form from Staphylococcus hominis complexed with an inhibitor, L-cycloserine.

Herman, R., Rudden, M., Wilkinson, A.J., Hanai, S., Thomas, G.H.

(2020) Sci Rep 10: 12500-12500

Released	2020-03-04
Method	X-RAY DIFFRACTION 1.42 Å
Organisms	Staphylococcus hominis
Macromolecule	Aminotransferase (protein)
Unique Ligands	LCS

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6QP2 \| pdb_00006qp2	Download File View File

Crystal structure of the PLP-bound C-S lyase from Staphylococcus hominis

Herman, R., Rudden, M., Wilkinson, A.J., Hanai, S., Thomas, G.H.

(2020) Sci Rep 10: 12500-12500

Released	2020-03-04
Method	X-RAY DIFFRACTION 1.6 Å
Organisms	Staphylococcus hominis unidentified
Macromolecule	Aminotransferase (protein) Polyhistidine tag (protein)
Unique Ligands	PLP

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6QP3 \| pdb_00006qp3	Download File View File

Crystal structure of the PLP-bound C-S lyase from Bacillus subtilis (strain 168)

Herman, R., Rudden, M., Wilkinson, A.J., Hanai, S., Thomas, G.H.

(2020) Sci Rep 10: 12500-12500

Released	2020-03-04
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Bacillus subtilis subsp. subtilis str. 168
Macromolecule	Cystathionine beta-lyase PatB (protein)
Unique Ligands	ACT, PLP

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6YKG \| pdb_00006ykg	Download File View File

Structure-based exploration of selectivity for ATM inhibitors in Huntingtons disease

Van de Poel, A., Leonard, P.M., Lamers, M.B.A.C.

(2021) J Med Chem 64: 5018-5036

Released	2021-04-14
Method	X-RAY DIFFRACTION 3.12 Å
Organisms	Homo sapiens
Macromolecule	Phosphatidylinositol 3-kinase catalytic subunit type 3 (protein)
Unique Ligands	OZ8