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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Gene Name = "Faah"

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Search Summary

This query matches 22 Structures.

Refinements

Structure Determination Methodology

experimental (22)

Scientific Name of Source Organism

	Rattus norvegicus (17)
	Arabidopsis thaliana (5)

Taxonomy

Eukaryota (22)

Experimental Method

X-RAY DIFFRACTION (22)

Polymer Entity Type

Protein (22)

Refinement Resolution (Å)

	1.5 - 2.0 (3)
	2.0 - 2.5 (10)
	2.5 - 3.0 (5)
	3.0 - 3.5 (3)
	3.5 - 4.0 (1)

Release Date

	2000 - 2004 (1)
	2005 - 2009 (3)
	2010 - 2014 (12)
	2015 - 2019 (3)
	2020 - 2024 (3)

Enzyme Classification Name

Hydrolases (22)

Membrane Protein Annotation

	OPM (3)
	mpstruc (1)

Symmetry Type

	Asymmetric (6)
	Cyclic (18)

SCOP Classification

	Alpha and beta proteins (a/b) (17)
	Artifacts (4)

AllSelected

1 to 22 of 22 Structures

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1MT5 \| pdb_00001mt5	Download File View File

CRYSTAL STRUCTURE OF FATTY ACID AMIDE HYDROLASE

Bracey, M.H., Hanson, M.A., Masuda, K.R., Stevens, R.C., Cravatt, B.F.

(2002) Science 298: 1793-1796

Released	2002-12-18
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Rattus norvegicus
Macromolecule	Fatty-acid amide hydrolase (protein)
Unique Ligands	MAY

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3K7F \| pdb_00003k7f	Download File View File

Crystal Structure Analysis of a Phenhexyl/Oxazole/Carboxypyridine alpha-Ketoheterocycle Inhibitor Bound to a Humanized Variant of Fatty Acid Amide Hydrolase'

Mileni, M., Stevens, R.C., Boger, D.L.

(2010) J Med Chem 53: 230-240

Released	2009-12-01
Method	X-RAY DIFFRACTION 1.95 Å
Organisms	Rattus norvegicus
Macromolecule	Fatty-acid amide hydrolase 1 (protein)
Unique Ligands	CL, F2C, NA

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3K83 \| pdb_00003k83	Download File View File

Crystal Structure Analysis of a Biphenyl/Oxazole/Carboxypyridine alpha-ketoheterocycle Inhibitor Bound to a Humanized Variant of Fatty Acid Amide Hydrolase

Mileni, M., Stevens, R.C., Boger, D.L.

(2010) J Med Chem 53: 230-240

Released	2009-12-01
Method	X-RAY DIFFRACTION 2.251 Å
Organisms	Rattus norvegicus
Macromolecule	Fatty-acid amide hydrolase 1 (protein)
Unique Ligands	1DO, CL, F27

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3K84 \| pdb_00003k84	Download File View File

Crystal Structure Analysis of a Oleyl/Oxadiazole/pyridine Inhibitor Bound to a Humanized Variant of Fatty Acid Amide Hydrolase

Mileni, M., Stevens, R.C., Boger, D.L.

(2010) J Med Chem 53: 230-240

Released	2009-12-01
Method	X-RAY DIFFRACTION 2.25 Å
Organisms	Rattus norvegicus
Macromolecule	Fatty-acid amide hydrolase 1 (protein)
Unique Ligands	CL, K84

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3LJ6 \| pdb_00003lj6	Download File View File

3D-CRYSTAL STRUCTURE OF HUMANIZED-RAT FATTY ACID AMIDE HYDROLASE (FAAH) CONJUGATED WITH THE DRUG-LIKE UREA INHIBITOR PF-3845 at 2.42A RESOLUTION

Mileni, M., Stevens, R.C., Kamtekar, S.

(2010) J Mol Biology 400: 743-754

Released	2010-06-09
Method	X-RAY DIFFRACTION 2.42 Å
Organisms	Rattus norvegicus
Macromolecule	Fatty-acid amide hydrolase 1 (protein)
Unique Ligands	CL, PIX

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3LJ7 \| pdb_00003lj7	Download File View File

3D-crystal structure of humanized-rat fatty acid amide hydrolase (FAAH) conjugated with Carbamate inhibitor URB597

Mileni, M., Stevens, R.C., Kamtekar, S.

(2010) J Mol Biology 400: 743-754

Released	2010-06-09
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Rattus norvegicus
Macromolecule	Fatty-acid amide hydrolase 1 (protein)
Unique Ligands	CL, OHO

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3OJ8 \| pdb_00003oj8	Download File View File

Alpha-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase Containing Additional Conformational Contraints in the Acyl Side Chain

Mileni, M., Stevens, R.C., Boger, D.L.

(2011) J Med Chem 54: 2805-2822

Released	2011-07-06
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Rattus norvegicus
Macromolecule	Fatty-acid amide hydrolase 1 (protein)
Unique Ligands	CL, OJ8

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3PPM \| pdb_00003ppm	Download File View File

Crystal Structure of a Noncovalently Bound alpha-Ketoheterocycle Inhibitor (Phenhexyl/Oxadiazole/Pyridine) to a Humanized Variant of Fatty Acid Amide Hydrolase

Mileni, M., Han, G.W., Boger, D.L., Stevens, R.C.

(2011) J Am Chem Soc 133: 4092-4100

Released	2011-11-09
Method	X-RAY DIFFRACTION 1.78 Å
Organisms	Rattus norvegicus
Macromolecule	Fatty-acid amide hydrolase 1 (protein)
Unique Ligands	1DO, CL, F, JG1, PEG

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3PR0 \| pdb_00003pr0	Download File View File

Crystal Structure of a Covalently Bound alpha-Ketoheterocycle Inhibitor (Phenhexyl/Oxadiazole/Pyridine) to a Humanized Variant of Fatty Acid Amide Hydrolase

Mileni, M., Han, G.W., Boger, D.L., Stevens, R.C.

(2011) J Am Chem Soc 133: 4092-4100

Released	2011-11-16
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Rattus norvegicus
Macromolecule	Fatty Acid Amide Hydrolase 1 (protein)
Unique Ligands	CL, JG2, PEG

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3QJ8 \| pdb_00003qj8	Download File View File

Crystal structure of fatty acid amide hydrolase

Min, X., Walker, N.P.C., Wang, Z.

(2011) Proc Natl Acad Sci U S A 108: 7379-7384

Released	2011-04-27
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Rattus norvegicus
Macromolecule	Fatty-acid amide hydrolase 1 (protein)

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3QJ9 \| pdb_00003qj9	Download File View File

Crystal structure of fatty acid amide hydrolase with small molecule inhibitor

Min, X., Walker, N.P.C., Wang, Z.

(2011) Proc Natl Acad Sci U S A 108: 7379-7384

Released	2011-04-27
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Rattus norvegicus
Macromolecule	Fatty-acid amide hydrolase 1 (protein)
Unique Ligands	EDO, GOL, PGE, QJ9

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3QK5 \| pdb_00003qk5	Download File View File

Crystal structure of fatty acid amide hydrolase with small molecule inhibitor

Min, X., Walker, N.P.C., Wang, Z.

(2011) Bioorg Med Chem Lett 21: 2492-2496

Released	2011-04-06
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Rattus norvegicus
Macromolecule	Fatty-acid amide hydrolase 1 (protein)
Unique Ligands	EDO, GOL, QK5

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3QKV \| pdb_00003qkv	Download File View File

Crystal structure of fatty acid amide hydrolase with small molecule compound

Min, X., Walker, N.P.C., Wang, Z.

(2011) Proc Natl Acad Sci U S A 108: 7379-7384

Released	2011-04-27
Method	X-RAY DIFFRACTION 3.1 Å
Organisms	Rattus norvegicus
Macromolecule	Fatty-acid amide hydrolase 1 (protein)
Unique Ligands	QKV

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4DO3 \| pdb_00004do3	Download File View File

Structure of FAAH with a non-steroidal anti-inflammatory drug

Garau, G.

(2013) J Am Chem Soc 135: 22-25

Released	2013-01-23
Method	X-RAY DIFFRACTION 2.25 Å
Organisms	Rattus norvegicus
Macromolecule	Fatty-acid amide hydrolase 1 (protein)
Unique Ligands	0LA, CL, OHO

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4HBP \| pdb_00004hbp	Download File View File

Crystal Structure of FAAH in complex with inhibitor

Behnke, C., Skene, R.J.

(2013) Bioorg Med Chem 21: 28-41

Released	2013-02-06
Method	X-RAY DIFFRACTION 2.91 Å
Organisms	Rattus norvegicus
Macromolecule	Fatty-acid amide hydrolase 1 (protein)
Unique Ligands	17J

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4J5P \| pdb_00004j5p	Download File View File

Crystal Structure of a Covalently Bound alpha-Ketoheterocycle Inhibitor (Phenhexyl/Oxadiazole/Pyridine) to a Humanized Variant of Fatty Acid Amide Hydrolase

Otrubova, K., Brown, M., McCormick, M.S., Han, G.W., O'Neal, S.T., Cravatt, B.F., Stevens, R.C., Lichtman, A.H., Boger, D.L.

(2013) J Am Chem Soc 135: 6289-6299

Released	2013-05-01
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Rattus norvegicus
Macromolecule	Fatty-acid amide hydrolase 1 (protein)
Unique Ligands	BR1, CL, PEG