Crystal Structures of Bovine Endothelial Nitric Oxide Synthase Heme Domain Complexed With Various Inhibitors
Raman, C.S., Li, H., Martasek, P., Southan, G.J., Masters, B.S.S., Poulos, T.L.To be published.
Experimental Data Snapshot
Entity ID: 1 | |||||
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Molecule | Chains | Sequence Length | Organism | Details | Image |
NITRIC OXIDE SYNTHASE | 444 | Bos taurus | Mutation(s): 0 EC: 1.14.13.39 | ||
UniProt | |||||
Find proteins for P29473 (Bos taurus) Explore P29473 Go to UniProtKB: P29473 | |||||
Entity Groups | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | P29473 | ||||
Sequence AnnotationsExpand | |||||
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Ligands 6 Unique | |||||
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ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
HEM Query on HEM | E [auth A], M [auth B] | PROTOPORPHYRIN IX CONTAINING FE C34 H32 Fe N4 O4 KABFMIBPWCXCRK-RGGAHWMASA-L | |||
HRG Query on HRG | F [auth A], N [auth B] | L-HOMOARGININE C7 H16 N4 O2 QUOGESRFPZDMMT-YFKPBYRVSA-N | |||
CAC Query on CAC | D [auth A], K [auth B] | CACODYLATE ION C2 H6 As O2 OGGXGZAMXPVRFZ-UHFFFAOYSA-M | |||
GOL Query on GOL | G [auth A], H [auth A], I [auth A], O [auth B], P [auth B] | GLYCEROL C3 H8 O3 PEDCQBHIVMGVHV-UHFFFAOYSA-N | |||
ZN Query on ZN | L [auth B] | ZINC ION Zn PTFCDOFLOPIGGS-UHFFFAOYSA-N | |||
ACT Query on ACT | C [auth A], J [auth B] | ACETATE ION C2 H3 O2 QTBSBXVTEAMEQO-UHFFFAOYSA-M |
Length ( Å ) | Angle ( ˚ ) |
---|---|
a = 58.96 | α = 90 |
b = 105.99 | β = 90 |
c = 156.6 | γ = 90 |
Software Name | Purpose |
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CNS | refinement |
DENZO | data reduction |
CCP4 | data scaling |
CNS | phasing |