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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Gene Name = "TEAD2"

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Search Summary

This query matches 37 Structures.

Refinements

Structure Determination Methodology

experimental (37)

Scientific Name of Source Organism

Homo sapiens (37)

Taxonomy

Eukaryota (37)

Experimental Method

X-RAY DIFFRACTION (37)

Polymer Entity Type

Protein (37)

Refinement Resolution (Å)

	1.5 - 2.0 (7)
	2.0 - 2.5 (26)
	2.5 - 3.0 (4)

Release Date

	2010 - 2014 (1)
	2015 - 2019 (5)
	2020 - 2024 (25)
	2025 - 2029 (6)

Symmetry Type

	Asymmetric (34)
	Cyclic (3)

SCOP Classification

	All beta proteins (15)
	Artifacts (3)

AllSelected

1 to 25 of 37 Structures

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3L15 \| pdb_00003l15	Download File View File

Human Tead2 transcriptional factor

Tomchick, D.R., Luo, X., Tian, W.

(2010) Proc Natl Acad Sci U S A 107: 7293-7298

Released	2010-04-07
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Transcriptional enhancer factor TEF-4 (protein)
Unique Ligands	GOL

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5DQ8 \| pdb_00005dq8	Download File View File

Crystal structure of human transcription factor TEAD2 in complex with flufenamic acid

Han, X., Luo, X.

(2015) Structure 23: 2076-2086

Released	2015-11-25
Method	X-RAY DIFFRACTION 2.305 Å
Organisms	Homo sapiens
Macromolecule	Transcriptional enhancer factor TEF-4 (protein)
Unique Ligands	FLF

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5DQE \| pdb_00005dqe	Download File View File

Crystal structure of human transcription factor TEAD2 in complex with bromo-fenamic acid

Han, X., Luo, X.

(2015) Structure 23: 2076-2086

Released	2015-11-25
Method	X-RAY DIFFRACTION 2.183 Å
Organisms	Homo sapiens
Macromolecule	Transcriptional enhancer factor TEF-4 (protein)
Unique Ligands	5E4

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5EMV \| pdb_00005emv	Download File View File

Crystal structure of the palmitoylated human TEAD2 transcription factor

Noland, C.L., Gierke, S., Schnier, P.D., Murray, J., Sandoval, W.N., Sagolla, M., Dey, A., Hannoush, R.N., Fairbrother, W.J., Cunningham, C.N.

(2016) Structure 24: 179-186

Released	2015-12-23
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Transcriptional enhancer factor TEF-4 (protein)

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5HGU \| pdb_00005hgu	Download File View File

Crystal structure of human transcription factor TEAD2 in complex with palmitate

Luo, X., Xiao, H.

(2016) Nat Chem Biol 12: 282-289

Released	2016-02-17
Method	X-RAY DIFFRACTION 2.046 Å
Organisms	Homo sapiens
Macromolecule	Transcriptional enhancer factor TEF-4 (protein)
Unique Ligands	PLM

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6CDY \| pdb_00006cdy	Download File View File

Crystal structure of TEAD complexed with its inhibitor

LIU, S., HAN, X., LUO, X.

(2020) Cell Stem Cell 26: 675-692.e8

Released	2020-07-01
Method	X-RAY DIFFRACTION 2.32 Å
Organisms	Homo sapiens
Macromolecule	Transcriptional enhancer factor TEF-4 (protein)
Unique Ligands	EY1

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6E5G \| pdb_00006e5g	Download File View File

Crystal structure of human TEAD2-Yap binding domain covalently bound to an allosteric regulator

Bum-Erdene, K., Gonzalez-Gutierrez, G., Meroueh, S.O.

(2019) Cell Chem Biol 26: 378

Released	2019-01-09
Method	X-RAY DIFFRACTION 2.43 Å
Organisms	Homo sapiens
Macromolecule	Transcriptional enhancer factor TEF-4 (protein)
Unique Ligands	HUY

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6S60 \| pdb_00006s60	Download File View File

Crystal structure of hTEAD2 in complex with a trisubstituted pyrazole inhibitor

Sturbaut, M., Allemand, F., Guichou, J.F.

(2021) Eur J Med Chem 226: 113835-113835

Released	2020-07-22
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Transcriptional enhancer factor TEF-4 (protein)
Unique Ligands	KX8, MYR

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6S64 \| pdb_00006s64	Download File View File

Crystal structure of hTEAD2 in complex with a trisubstituted pyrazole inhibitor

Sturbaut, M., Allemand, F., Guichou, J.F.

(2021) Eur J Med Chem 226: 113835-113835

Released	2020-07-22
Method	X-RAY DIFFRACTION 2.22 Å
Organisms	Homo sapiens
Macromolecule	Transcriptional enhancer factor TEF-4 (protein)
Unique Ligands	KXE, MYR, PLM

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6S66 \| pdb_00006s66	Download File View File

Crystal structure of hTEAD2 in complex with a trisubstituted pyrazole inhibitor

Sturbaut, M., Allemand, F., Guichou, J.F.

(2021) Eur J Med Chem 226: 113835-113835

Released	2020-07-22
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	Transcriptional enhancer factor TEF-4 (protein)
Unique Ligands	KWW, MYR

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6S69 \| pdb_00006s69	Download File View File

Crystal structure of hTEAD2 in complex with a trisubstituted pyrazole inhibitor

Sturbaut, M., Allemand, F., Guichou, J.F.

(2021) Eur J Med Chem 226: 113835-113835

Released	2020-07-22
Method	X-RAY DIFFRACTION 2.15 Å
Organisms	Homo sapiens
Macromolecule	Transcriptional enhancer factor TEF-4 (protein)
Unique Ligands	KX5, MYR

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6S6J \| pdb_00006s6j	Download File View File

Crystal structure of hTEAD2 in complex with a trisubstituted pyrazole inhibitor

Sturbaut, M., Allemand, F., Guichou, J.F.

(2021) Eur J Med Chem 226: 113835-113835

Released	2020-07-22
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	Transcriptional enhancer factor TEF-4 (protein)
Unique Ligands	KXH, MYR

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6UYB \| pdb_00006uyb	Download File View File

Crystal structure of TEAD2 bound to Compound 1

Noland, C.L., Holden, J.K., Crawford, J.J., Zbieg, J.R., Cunningham, C.N.

(2020) Cell Rep 31: 107809-107809

Released	2020-06-24
Method	X-RAY DIFFRACTION 1.543 Å
Organisms	Homo sapiens
Macromolecule	Transcriptional enhancer factor TEF-4 (protein)
Unique Ligands	GOL, QSJ, TRS

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6UYC \| pdb_00006uyc	Download File View File

Crystal structure of TEAD2 bound to Compound 2

Noland, C.L., Holden, J.K., Crawford, J.J., Zbieg, J.R., Cunningham, C.N.

(2020) Cell Rep 31: 107809-107809

Released	2020-06-24
Method	X-RAY DIFFRACTION 1.658 Å
Organisms	Homo sapiens
Macromolecule	Transcriptional enhancer factor TEF-4 (protein)
Unique Ligands	QLV, TRS

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6VAH \| pdb_00006vah	Download File View File

Crystal structure of human TEAD2 transcription factor in complex with Flufenamic acid derivative

Halabelian, L., Zeng, H., Dong, A., Li, Y., Melin, L., Gagnon, A., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Santhakumar, V., Structural Genomics Consortium (SGC)

To be published

Released	2020-04-15
Method	X-RAY DIFFRACTION 2.11 Å
Organisms	Homo sapiens
Macromolecule	Transcriptional enhancer factor TEF-4 (protein)
Unique Ligands	QZ1, UNX

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7OYJ \| pdb_00007oyj	Download File View File

Crystal structure of hTEAD2 in complex with fragment at the interface 2

Guichou, J.F., Gelin, M., Allemand, F.

(2022) J Med Chem 65: 5926-5940

Released	2022-05-25
Method	X-RAY DIFFRACTION 1.91 Å
Organisms	Homo sapiens
Macromolecule	Transcriptional enhancer factor TEF-4 (protein)
Unique Ligands	3DI, PLM

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7T2J \| pdb_00007t2j	Download File View File

Crystal Structure of TEAD2 in a covalent complex with TED-642

Bum-Erdene, K., Gonzalez-Gutierrez, G., Meroueh, S.O.

(2023) J Med Chem 66: 266-284

Released	2023-06-14
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Homo sapiens
Macromolecule	Transcriptional enhancer factor TEF-4 (protein)
Unique Ligands	E8Y

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7T2K \| pdb_00007t2k	Download File View File

Crystal Structure of TEAD2 in a covalent complex with TED-661

Bum-Erdene, K., Gonzalez-Gutierrez, G., Meroueh, S.O.

(2023) J Med Chem 66: 266-284

Released	2023-06-14
Method	X-RAY DIFFRACTION 2.34 Å
Organisms	Homo sapiens
Macromolecule	Transcriptional enhancer factor TEF-4 (protein)
Unique Ligands	ED0

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7T2L \| pdb_00007t2l	Download File View File

Crystal Structure of TEAD2 in a covalent complex with TED-662

Bum-Erdene, K., Gonzalez-Gutierrez, G., Meroueh, S.O.

(2023) J Med Chem 66: 266-284

Released	2023-06-14
Method	X-RAY DIFFRACTION 2.15 Å
Organisms	Homo sapiens
Macromolecule	Transcriptional enhancer factor TEF-4 (protein)
Unique Ligands	EFI

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7T2M \| pdb_00007t2m	Download File View File

Crystal Structure of TEAD2 in a covalent complex with TED-664

Bum-Erdene, K., Gonzalez-Gutierrez, G., Meroueh, S.O.

(2023) J Med Chem 66: 266-284

Released	2023-06-14
Method	X-RAY DIFFRACTION 2.81 Å
Organisms	Homo sapiens
Macromolecule	Transcriptional enhancer factor TEF-4 (protein)
Unique Ligands	EGK

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7TYP \| pdb_00007typ	Download File View File

TEAD2 bound to GNE-7883

Noland, C.L., Fong, R.

To be published

Released	2023-05-03
Method	X-RAY DIFFRACTION 1.6 Å
Organisms	Homo sapiens
Macromolecule	Transcriptional enhancer factor TEF-4 (protein)
Unique Ligands	KUR, TRS

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7TYQ \| pdb_00007tyq	Download File View File

TEAD2 bound to Compound 1

Noland, C.L., Fong, R.

To be published

Released	2023-05-03
Method	X-RAY DIFFRACTION 1.88 Å
Organisms	Homo sapiens
Macromolecule	Transcriptional enhancer factor TEF-4 (protein)
Unique Ligands	KUI

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7TYU \| pdb_00007tyu	Download File View File

TEAD2 bound to Compound 2

Noland, C.L., Fong, R.

To be published

Released	2023-05-03
Method	X-RAY DIFFRACTION 1.78 Å
Organisms	Homo sapiens
Macromolecule	Transcriptional enhancer factor TEF-4 (protein)
Unique Ligands	KTF, TRS

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8CUH \| pdb_00008cuh	Download File View File

Crystal structure of human TEAD2 complexed with its inhibitor TM2.

Liu, S., Luo, X.

(2022) Elife 11:

Released	2022-11-23
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Transcriptional enhancer factor TEF-4 (protein)
Unique Ligands	P0I

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8E1O \| pdb_00008e1o	Download File View File

Crystal structure of hTEAD2 bound to a methoxypyridine lipid pocket binder

Noland, C.L., Dey, A., Zbieg, J., Crawford, J.

(2024) bioRxiv

Released	2023-08-16
Method	X-RAY DIFFRACTION 2.25 Å
Organisms	Homo sapiens
Macromolecule	Transcriptional enhancer factor TEF-4 (protein)
Unique Ligands	TRS, Y2S

1 to 25 of 37 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Symmetry Type

SCOP Classification

3L15 | pdb_00003l15

5DQ8 | pdb_00005dq8

5DQE | pdb_00005dqe

5EMV | pdb_00005emv

5HGU | pdb_00005hgu

6CDY | pdb_00006cdy

6E5G | pdb_00006e5g

6S60 | pdb_00006s60

6S64 | pdb_00006s64

6S66 | pdb_00006s66

6S69 | pdb_00006s69

6S6J | pdb_00006s6j

6UYB | pdb_00006uyb

6UYC | pdb_00006uyc

6VAH | pdb_00006vah

7OYJ | pdb_00007oyj

7T2J | pdb_00007t2j

7T2K | pdb_00007t2k

7T2L | pdb_00007t2l

7T2M | pdb_00007t2m

7TYP | pdb_00007typ

7TYQ | pdb_00007tyq

7TYU | pdb_00007tyu

8CUH | pdb_00008cuh

8E1O | pdb_00008e1o